If the antivirus software is utilizing real-time protection, or if the scan of that directory happens at just the exact wrong time, corruption can occur. Imagine antivirus software locking an entire directory full of files that need to be processed by a Windows service designed open the files and then merge the content into a SQL database. So, unless properly configured, antivirus software can lock files and entire directories, causing server issues that are hard to pinpoint. But, the truth is that antivirus applications are designed to protect the operating system from known vulnerabilities and outbreaks, not the applications that are installed to run on top. With the many antivirus vendors offering their products for so long, you'd think they would have made adjustments by now to work better with the products they are intended to protect. You might be surprised at how many server and server product problems can actually be tied back to antivirus software. Over the years, I've seen many different documents pop up, and they have all been tied a specific area of admin focus. For years communities have had to create their own best practice documents for proper antivirus software exclusions.
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